As I've related here before I've met several highly capable, independent people who've either built one or more business or a very impressive career here, that simply left...
This has been a trend for decades too, the real risk takers left a long time ago, some failed of course, but many did very well and never really looked back.
The one thing that is changing now is global taxation, this is clearly planned to happen in the next few years. Many of the really capable people will relocate again, or even do the nomad game for as long as possible.
But what then? I hope that Europe gets to a stage where its bleedingly obvious that it all has to go, like the Soviet Union.
Some will be able to get early in on this, maybe returning to build on Bitcoin in open defiance!