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you can use nix on ubuntu, and keep your regular package manager side by side, they won't interfere with each other.
idk about hardware wallets, but I know Pavol Rusnak at Trezor is a Nix fan and contributor. don't think their wallet uses NixOS though.
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Ahh not for your regular windows/Ubuntu user. NPM package manager types no longer needed with nix. Do you know of any hardware that ships with only nix as its OS?