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Even if there is a higher association of NAION caused by these drugs, I would want to know how that compares to the greater risk of diabetic retinopathy. I have seen NAION less than a handful of times, whereas I see diabetic retinopathy and other complications of diabetes every day.
Too lazy to look up actual numbers with cited sources but O1 vibe check says:
NAION: Often cited around 2–10 per 100,000 persons per year (for individuals over 50). Diabetic Retinopathy : Multiple large-scale studies (e.g., NHANES in the United States) have reported that anywhere from 20% to 40% (or more) of people with diabetes show some level of retinopathy Putting It All Together:
- NAION in diabetics: Elevated risk vs. non-diabetics, but still a relatively uncommon event.
- Diabetic Retinopathy (and its advanced stages) is very common in long-standing diabetes—often cited as the leading cause of new cases of blindness among working-age adults in many countries.
yeah i saw that study floating around twitter a few months ago (but admittedly did not read).
Would be curious to see if that association holds with the newer meds. My gut (lowest tier of evidence) from seeing patients who would never give up these and talking to docs who prescribe thinks there is 4-5x or greater benefit over any risks from cardiovascular risks from eliminating being a fatty and controlling diabetes.
Just standard fear mongering.
I've never prescribed these drugs in my life but on the inpatient side I've seen very few side effects but so many cases of patients who have told me they have lost 50+ pounds and gotten off of multiple other drugs as a result of their weight loss.
Healthy young people and fitness professionals love to virtue signal on social media about the right way to do things but in the real world people have 3 kids, back and knee problems, job stress etc and 90% of people gain the weight back and more after 3 years regardless of fad diet.
Haven't had a chance to listen to the JRE podcast (hard to commit to such a long podcast) but I really enjoyed Magnus' interview on the In Good Company podcast:
I never understand these buyouts... how are they supposed to get ROI on $116m when they will likely dump the entire product?
I felt rather tall in Japan... it's rather amazing to me that this freak came out of nowhere to be possibly the baseball GOAT.
I think this is becoming increasingly popular. In this interview on MFM this guy claims to be 100% in on BTC since 2013 but then claims it's all via third party custody.
No one wants to paint a target on themselves unnecessarily.
Well my vision of the future is pretty dystopian lol
Gun rights were great in theory to safeguard against a tyrannical gov through the 20th century, but will be completely inept against a AI weaponry of the very near future.
Putting aside my other dystopian AI fears, I don't see how we "stop the train" as Lyn says, at which point everything we take for granted unravels...
Yup! The purity clerics are annoying. Goal is to stack sats...
I'm still not quite sure where the yield comes from though... if I make a 20k tax payment I'm getting $100 back in BTC (minus the $3 fee)... great for me but seems like quite an expensive transaction cost for them to recoup at scale.
Libertarians simply cannot survive in the modern world. I've come to believe that freedom of speech and western ideals will not persist unless the USA continues to flourish. As Europe commits seppuku, without the threat of the US and its military might, there is no deterrent that keeps China, Russia and other countries from expanding their empires.
Your homestead farm with your bunker, your neighborhood militia, and feeble gun collection will never survive a modern drone swarm attack, or defend against a pack of armed robot dogs.
Very soon with universal surveillance enabled by AI you will never again be able to mount an organized protest, much less an effective attack against a totalitarian government. See how quickly protestors in HK and Russia have disappeared.
So the dominant US state must continue to thrive, for libertarians to live their little fantasies elsewhere throughout the world. Unfortunately it will not survive if the USD goes to zero and enters an irrecoverable debt spiral into bankruptcy.
what was Fold before the debit card?
Man 2021 was the glory days… I was regularly getting such high % back by saving daily spins and from small purchases and using them strategically on bigger purchases.
I don’t know squat about banks but I love my Fold card. It’s been fun to see the fiat value of those sats creep up this past year.
I presume the 97 billion is just enough to get a controlling stake in OpenAI. Per twitteratti Elon's reasoning was to increase the overall paper valuation of the company which would throw a wrench in the non-profit -> for-profit conversion somehow as there's some sort of buy-out required to the non-profit portion and this would increase that amount.
I feel like I barely use google anymore, except to find stuff I already know exists, or to use "site:reddit.com search".
I'm always going to perplexity or chatgpt now... the golden goose is coming to an end quickly once people get more comfortable using AI