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21 sats \ 0 replies \ @02a9a61fdc OP 3 Apr \ parent \ on: Frequent blood donations as an evolutionary factor science
They analysed the blood of persons over 60. So the amount of donations accumulated over a lifetime. But you are right, they had to donate several times for many decades.
I guess in a certain context these mutations are useful. After blood loss EPO stimulates the growth of new red blood cells. So if they lost a lot of blood these individuals probably had a slight advantage because their body would form new blood cells faster compared to the controls.