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For me,it's the expansion of the universe(into what is it expanding?)and how it might end,by a big crunch or big freeze?
nd what about you? 👀

How to describe gravity with a single theory that gives repeatable predictions, that is consistent with both general relativity and with quantum mechanics. This to me is the biggest unanswered physics problem of our age, and whoever answers it will be on a par with Einstein.

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Interesting
Do you think we could get an answer for this in next few decades?

"How did life come about?"

For many scientists, the primordial soup theory in which chemical processes from the ocean mixed with gases from the atmosphere and energy from lightning may be the best theory to explain how life arose on Earth.
But it is not universally accepted nor is it the only one.
In fact, there is no agreement about life or where it began.

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water..
Science cant really fully explain it

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Really?