As for myself, I haven't muted any territory yet. I might in a hopefully not-too-distant future when too much SN activity hides the good content too quickly. Now, especially in my timezone, it's usually calm enough for a big part of the day to catch the good content in recent that doesn't make it to the hot page because of different interests.

I only muted a few users as I noticed they managed to disrupt my pleasant SN experience. The thing I noticed then though is that when I see in a thread comment by someone you muted it ends up triggering my curiosity and I read the comment after all. I'd rather have it to be unclickable, where I'd have to unblock the user if I really want to read it.

Thanks for the comments, it's interesting to read people's different behaviors.