Hm... Satoshi wasted in theory at least one byte then. In practice 2. Anyway. I was thinking in the context that I wish bitcoin was more divisible. And it clearly it was possible for bitcoin to be more divisible if one bitcoin was defined as a bigger integer (and the initial reward was still 50 btc) without actually sacrificing anything.

I feel that it may be possible in the future 1 satoshi to be too big of a value. And as far as I have read this cannot be fixed without some very disruptive hard fork. (And yeah, subsatoshi on the lightning network is not the same as it can't really be settled).