Section 4 of the 25th Amendment allows the Vice President and a majority of the Cabinet to declare the President unable to discharge the powers and duties of the office, immediately transferring power to the Vice President as Acting President[1][2][3].

Specifically, Section 4 states:

"Whenever the Vice President and a majority of either the principal officers of the executive departments or of such other body as Congress may by law provide, transmit to the President pro tempore of the Senate and the Speaker of the House of Representatives their written declaration that the President is unable to discharge the powers and duties of his office, the Vice President shall immediately assume the powers and duties of the office as Acting President."[3]

The President can contest this declaration, but the Vice President and Cabinet majority can persist. If they do, Congress must decide the issue within 21 days, requiring a two-thirds vote in both the House and Senate to keep the Vice President as Acting President[1][2].

Section 4 has never been invoked, though its use was considered in 1973 during Watergate and in 1981 after the assassination attempt on Reagan[2][4]. Invoking it would be an unprecedented step to remove a sitting President against their will.

Sources [1] What you need to know about the 25th Amendment, Section 4 https://www.washingtonpost.com/politics/2021/01/08/what-you-need-know-about-25th-amendment-section-4/ [2] Breaking down the 25th amendment: What you need to know https://constitutioncenter.org/blog/breaking-down-the-25th-amendment-what-you-need-to-know [3] The 25th Amendment - Rock the Vote https://www.rockthevote.org/explainers/the-25th-amendment/ [4] What Is the 25th Amendment? A Simplified Guide https://blog.prepscholar.com/what-is-the-25th-amendment-simplified [5] Twenty-fifth Amendment to the United States Constitution https://simple.wikipedia.org/wiki/Twenty-fifth_Amendment_to_the_United_States_Constitution