One thing to be cognizant of, is that sudo does some tricks to integrate with your current session, which run0 may not do...so I don't think it will be a "drop in" replacement.

Example:

$ export TEST=hello
$ echo $TEST
hello
$ sudo echo $TEST
hello

You can see that sudo has inherited the local variables to make things work in a more seemless manner. From what I've read, run0 is the equivalent of logging in as root, thus will probably not (by default) inherit local variables.