QubesOS has wonderful security by way of jt's novel approach to virtualizing application workdlows, but it's a PITA to setup and use so I often avoid using my Qubes rig if I don't have to.
For my daily driver, I find that I much prefer VanillaOS. See the other comment for details.
Lately I've been running VanillaOS to improve the Linux desktop experience by isolating the root operating system in an immutable boot partition using abroot and installs all applications in userspace via containerization.
This affords the user better security but also better UX since users can install apps from any package manager (snap, flatpak, AppImage, nix, apt, dnf, pacman) thanks to apx which installs and seamlessly integrates apps into distro-specific containers.
Desktop Linux distributions, including Debian, Fedora, Ubuntu, Arch, Gentoo, all suffer from a complete neglect of basic security principles. Windows 11 pro and good antivirus like kaspersky on a dell precision workstation is magnitudes better than any Linux.
With Linux your bitcoin will be gone in 1..2..3
curl | shanything and they'll be fine.