There will still be entrepreneurs who discover profit opportunities and people with bitcoin reserves to help with funding.
Fixed money supply doesn't mean there's no economic growth. If a venture expects to make a profit, then they could afford to pay back a loan with interest.
I think you're probably imagining something like money vanishing after a loan is paid, rather than it going back into circulation. You could pay back a loan with the same bitcoin over and over again, if you happened to be earning it back between payments.
You bring up a good point - money is flowing through the system in a circular fashion way faster than my imagination suggests.
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