Not sure whether this would work but I'd be very interested to see if it could be done. I think the continual writing on to the SD, and db size will become a problem.

Even if the storage and other other specs seemed similar to a Pi, the difficulty to maintain regular upgrades, installing and uninstalling various tools.

If the question is for running a node in a fairly serious attempt to either route payments not just for your own payments, you'd need to maintain a synced blockchain, and keep synced to the lightning graph as much as possible.

I'd go with one of the other small form-factor cpus, nuc, laptop or desktop. Laptops work well for me.