This is a step by step guide to DIY mRNA vaccine production. The guy who wrote it, Phil Fung, used to run a lab startup.
the guide covers the entire process - from sequencing to synthesis, using open-source software and benchtop lab equipment.
Supposedly, Fung was inspired by the Australian guy who made a cancer treatment for his dog.
better to take the debian approach on that, let other "arch" enthusiasts test the new thing first. Then after a long time test we can decide better.