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Sorry when I mean genetics (outside of the obvious inherited disorders that appear early), I mean that some families seem to have many members live longer to late 80s and 90s while other families have lots of cancer or die in their 60s and 70s. If your grandparents and parents lived long it's a good sign.
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True, but if my grandma smoked a bunch and died early of lung cancer, that doesn't really tell me much about my cancer risk if I don't smoke.
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How much have age-adjusted cancer rates changed over time?
We know our underlying genetics aren't significantly different, so either that change is due to our luck changing or it's environmental.