Clascoterone 5% solution offers a novel mechanism for AGA, targeting androgen receptors locally with minimal systemic absorption.
Both trials demonstrated statistically significant improvements in hair growth compared with vehicle. In one study, clascoterone produced a 5.39-fold (539%) relative improvement in TAHC, while the second trial showed a 1.68-fold (168%) relative improvement. The magnitude of difference between the 2 studies is not unusual for hair-growth research, which often shows variability based on baseline disease severity, regional demographics, or site-level differences in assessment technique.
Clascoterone appears to be a topical DHT inhibitor, currently approved to treat some forms of acne, and studies purport it has less HPA axis suppression than other topical DHT inhibitors like Finasteride.
IMO even a full head of hair is not worth any amount of HPA axis suppression. While DHT isn't very anabolic, it's is basically THE male hormone, the body's most potent agonist of androgen receptors which regulate the genes for maleness. Just let yourself go bald and enjoy your dudeliness.