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What's different is that when you buy a trade in polymarket with Bitcoin, they will immediately convert it into USDC $hit, and when you win they will give you USDC. In the meantime if Bitcoin price appreciates is all your loss.

So, choose wisely.

At Predyx it's all done in Sats.
https://beta.predyx.com/market/stanley-cup-champion-2026-1759910573