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CMC, Kittle and Pearsall will be featured heavily early on. Even if JJ is ready for week 1, he hasn't practiced so highly doubt he will get a ton of targets. WR room will take shape after DeMarcus Robinson returns week 4 and Aiyuk in probably week 6.
This is very bad but Aiyuk, Pearsall, Jennings, Robinson is very solid. Need to get there though. That's why I said I wouldn't be too concerned if the 49ers were 4-4 and 3-5 isn't ideal but not the end of the world either.