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A slight genetic change in sapiens caused the extinction of many, many other species on Earth.
When the genetic change happened, people would have laughed that such a minor thing could make such a major impact.
Intelligence is the most powerful thing in the universe. I think this fact is under-appreciated by the average modern Sapien.
If humans aren't extinct by some other means, AI will inevitably be the cause of our extinction. I think people who disagree with this just don't think in long enough time horizons. It's absolutely obvious to me.