“Epidemiological studies have hinted that populations that live at higher altitudes tend to live longer and stay healthier as they age. We wanted to test whether, in a more controlled setting, restricting oxygen appears to do the same in our mouse model of aging”

The researchers utilized a strain of mice known for its accelerated aging, to test whether continuous exposure to low oxygen (11%) could delay aging-related decline. The study found that mice subjected to hypoxia lived 50% longer and demonstrated delayed neurological deterioration, particularly in motor coordination.