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Bats and humans have a gene called p53, a tumor-suppressor that can shut down cancer. (Mutations in p53, limiting its ability act properly, occur in about half of all human cancers.) A species known as the “little brown” bat—found in Rochester and upstate New York—contain two copies of p53 and have elevated p53 activity compared to humans. High levels of p53 in the body can kill cancer cells before they become harmful in a process known as apoptosis. If levels of p53 are too high, however, this is bad because it eliminates too many cells. But bats have an enhanced system that balances apoptosis effectively.
Bats have an extremely efficient immune system, knocking out multiple deadly pathogens. This also contributes to bats’ anti-cancer abilities by recognizing and wiping out cancer cells, Gorbunova says. As humans age, the immune system slows, and people tend to get more inflammation (in joints and other organs), but bats are good at controlling inflammation, too. This intricate system allows them to stave off viruses and age-related diseases.
I've been reading Zones of Thought and one of the many awesome passing ideas that comes up is synthetic immune systems. Immune systems really are just so freaking cool - like a cellular infantry.
50 sats \ 1 reply \ @gnilma 21h
Not related to the article, but whenever the topic of bats come up, I think of the Silverwing novel trilogy by Kenneth Oppel. Great stories, characters, and world building.
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50 sats \ 0 replies \ @k00b OP 21h
Cool, adding Silverwing to my shelf!
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Limitations of the study: Fibroblasts have been traditionally used for cross-species studies of malignant transformation, as other cell types require unique culture conditions that, in many cases, are species-specific and have not been established for the exotic species. However, requirements for malignant transformation may differ across cell types. Therefore, the conclusions of this study are limited to fibroblasts.
Unfortunately, there are these limitations. Either way, the study is important — how can we replicate this in a different species like ours?
Immune systems really are just so freaking cool - like a cellular infantry.
It’s incredible how the body recognizes attackers, creates the perfect antibodies for that intruder, and keeps a record of it to produce them faster next time. Not to mention that antibodies are some seriously badass cells.
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